Sepiapterin reductase (Spra and Sprb) regulate carotenoid and pteridine metabolism influencing the koi carp (Cyprinus carpio L.) coloration

The evolution of teleost coloration is strongly linked with the fish-specific genome duplication (FSGD).Sepiapterin reductase (Spr) is commonly required in pteridine pigment synthesis and two paralogs are found in teleosts.However, the functions of spra and sprb in pigmentation have not been completely elucidated.Here we found that spra was intensi

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Intrinsic Noise Profoundly Alters the Dynamics and Steady State of Morphogen-Controlled Bistable Genetic Switches.

During tissue development, patterns of gene expression determine the spatial arrangement of cell types.In many cases, gradients of secreted signalling molecules-morphogens-guide this process by controlling downstream transcriptional networks.A mechanism commonly used in these networks to convert the continuous information provided by the gradient i

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